Skip to main content
  • Home
  • About
  • Faculty Experts
  • For The Media
  • ’Cuse Conversations Podcast
  • Topics
    • Alumni
    • Events
    • Faculty
    • Students
    • All Topics
  • Contact
  • Submit
STEM
  • All News
  • Arts & Culture
  • Business & Economy
  • Campus & Community
  • Health & Society
  • Media, Law & Policy
  • STEM
  • Veterans
  • University Statements
  • Syracuse University Impact
  • |
  • The Peel
  • Athletics
Sections
  • All News
  • Arts & Culture
  • Business & Economy
  • Campus & Community
  • Health & Society
  • Media, Law & Policy
  • STEM
  • Veterans
  • University Statements
  • Syracuse University Impact
  • |
  • The Peel
  • Athletics
  • Home
  • About
  • Faculty Experts
  • For The Media
  • ’Cuse Conversations Podcast
  • Topics
    • Alumni
    • Events
    • Faculty
    • Students
    • All Topics
  • Contact
  • Submit
STEM

Engineering and Computer Science Faculty Awarded Grant for Catheter Research Project

Thursday, April 29, 2021, By Alex Dunbar
Share
BioInspiredCollege of Engineering and Computer SciencegrantNational Institutes of Health

For the 75 million people who require a urinary catheter, urinary tract infections are a serious concern. Catheters are prone to colonization by bacterial and fungal pathogens, which causes antibiotic-resistant infections. An infection can also lead to pH changes in the urine and block a catheter due to stone formation with potentially fatal consequences. Catheter associated urinary tract infections (CAUTIs) that are antibiotic resistant cause 13,000 deaths in the U.S. each year.

College of Engineering and Computer Science professors Dacheng Ren, Stevenson endowed professor of biomedical and chemical engineering and associate dean for research and graduate programs; Teng Zhang, assistant professor of mechanical and aerospace engineering; and Huan Gu, research assistant professor and Upstate Medical University’s Dmitriy Nikolavsky, MD, associate professor of Urology, were awarded an National Institutes of Health (NIH) R01 grant for a project aiming to engineer a new urinary catheter using smart biomaterials to reduce catheter associated complications.

group of researchers“Conventional antibiotics commonly fail to eradicate infections associated with medical devices because of the remarkable capabilities of microbes to colonize these surfaces and form drug-resistant biofilms. To solve this challenging problem, we need new strategies that can provide long-term protections. This R01 project gave us an exciting opportunity to do exactly that,” said Ren, the principal investigator of this project.

Ren’s lab has developed a new strategy designed to make catheters smarter and more resistant to infection. They successfully created micron-sized pillars with supermagnetic nanoparticles on the tip so the pillars can beat in response to an electromagnetic field generated using an insulated copper coil embedded in the catheter wall. By controlling the on and off of an electric current, they could turn the magnetic field on and off, and thus control the beating frequency and beating force of the pillars. This strategy (active topography) worked well, as these moving pillars prevented biofilm formation of multiple bacterial species by up to 99.9% compared to flat control surfaces. A prototype catheter with active topography remained clean for 30 days while the control catheters were blocked by biofilms of uropathogenic Escherichia coli within five days in an in vitro test with flow of a medium mimicking urine. Their study was published in a recent issue of Nature Communications.

Now Ren, Gu, Zhang and Nikolavsky will move forward and study the mechanism of infection control by such active topographies, and further engineer their catheter porotype for in vivo tests in this R01 project. By optimizing micron sized pillars on the catheter wall, they hope to develop a self-cleaning catheter that would be much safer for long term use.

“This strategy is inspired by the motile cilia in human airways that protects our lungs from foreign particles during respiration,” said Gu. “Thanks to the development in materials and surface engineering, we can replicate this defense strategy, make it more robust and adaptable, and apply it to address challenges such as biofilm-associated urinary tract infections in this project.”

Numerical simulations from Zhang’s lab and the collaboration with Nikolavsky in Upstate Medical University’s urology department are key components to the potentially groundbreaking work.

“Biofilms are highly complicated biological materials with active bacteria embedded in polymer networks. This poses challenges and provides opportunities to integrate mechanics modeling and simulations with well-controlled experiments to uncover the working mechanism and design principles of medical devices.”

Zhang has been collaborating with the Ren lab prior to this award and he is also a co-author of the Nature Communications paper.

If successful, the findings from this study may also help solve other infections that involve microbial biofilms, especially those associated with medical devices.

“I am very excited about this design of smart catheters, Bacterial colonization and biofilm formation on catheters, stents and other implantable devices is an enormous problem in medicine,” said Nikolavsky.  “Creating such smart surfaces on catheters that would actively expel pathogens, could potentially prevent bacterial colonization, catheter-associated urinary tract infections and may save patients with chronic catheters from bladder stone formation and recurrent catheter encrustation and clogging. I expect this will improve medical care and have positive effect on quality of life for many patients and prevent some of the common urological emergencies.”

  • Author

Alex Dunbar

  • Recent
  • The Racket About Padel: Newhouse Students Partner With Global Media Firm to Track Rise of Sport
    Friday, July 11, 2025, By Genaro Armas
  • From Wedding Day Pics on Campus to Working at ‘Otto’s House’: Brianna and Kevin Shults Share Their Orange Love Story
    Friday, July 11, 2025, By Jen Plummer
  • Vintage Over Digital: Alumnus Dan Cohen’s Voyager CD Bag Merges Music and Fashion
    Monday, July 7, 2025, By John Boccacino
  • Empowering Learners With Personalized Microcredentials, Stackable Badges
    Thursday, July 3, 2025, By Hope Alvarez
  • WISE Women’s Business Center Awarded Grant From Empire State Development, Celebrates Entrepreneur of the Year Award
    Thursday, July 3, 2025, By Dawn McWilliams

More In STEM

6 A&S Physicists Awarded Breakthrough Prize

Our universe is dominated by matter and contains hardly any antimatter, a notion which still perplexes top scientists researching at CERN’s Large Hadron Collider. The Big Bang created equal amounts of matter and antimatter, but now nearly everything—solid, liquid, gas or plasma—is…

Setting the Standard and Ensuring Justice

Everyone knows DNA plays a crucial role in solving crimes—but what happens when the evidence is of low quantity, degraded or comes from multiple individuals? One of the major challenges for forensic laboratories is interpreting this type of DNA data…

Student Innovations Shine at 2025 Invent@SU Presentations

Eight teams of engineering students presented designs for original devices to industry experts and investors at Invent@SU Final Presentations. This six-week summer program allows students to design, prototype and pitch their inventions to judges. During the program, students learn about…

WiSE Hosts the 2025 Norma Slepecky Memorial Lecture and Undergraduate Research Prize Award Ceremony

This spring, Women in Science and Engineering (WiSE) held its annual Norma Slepecky Memorial Lecture and Award Ceremony. WiSE was honored to host distinguished guest speaker Joan-Emma Shea, who presented “Self-Assembly of the Tau Protein: Computational Insights Into Neurodegeneration.” Shea…

Endowed Professorship Recognizes Impact of a Professor, Mentor and Advisor

Bao-Ding “Bob” Cheng’s journey to Syracuse University in pursuit of graduate education in the 1960s was long and arduous. He didn’t have the means for air travel, so he voyaged more than 5,000 nautical miles by boat from his home…

Subscribe to SU Today

If you need help with your subscription, contact sunews@syr.edu.

Connect With Us

  • X
  • Facebook
  • Instagram
  • Youtube
  • LinkedIn
Social Media Directory

For the Media

Find an Expert Follow @SyracuseUNews
  • Facebook
  • Instagram
  • Youtube
  • LinkedIn
  • @SyracuseU
  • @SyracuseUNews
  • Social Media Directory
  • Accessibility
  • Privacy
  • Campus Status
  • Syracuse.edu
© 2025 Syracuse University News. All Rights Reserved.