SU News Services
(315) 443-3784
An estimated 25,000 Americans develop severe fungal infections each year, leading to 10,000 deaths despite the use of anti-fungal drugs. The associated cost to the U.S. health care system has been estimated at $1 billion a year.
Now two Syracuse University scientists have developed new brominated furanones that exhibit powerful anti-fungal properties.
The most virulent fungus is Candida albicans, which is carried by about 75 percent of the public. Typically the fungus is harmless but, in individuals with HIV or otherwise compromised immune systems, it can cause candidiasis, which has a high mortality rate. The fungi can also form biofilms that attach to surfaces and are up to 1,000 times more resistant to anti-fungals.
“These new furanones have the potential to control such infections and save lives,” says assistant professor Dacheng Ren of the Department of Biomedical and Chemical Engineering in SU’s L.C. Smith College of Engineering and Computer Science. “In our tests, they reduced fungal growth by more than 80 percent, and we hope to improve on that going forward.”
Ren and his collaborator, chemistry professor Yan-Yeung Luk of SU’s College of Arts and Sciences, have filed a non-provisional patent application. They have also published related results in the Journal of Applied Microbiology and Biotechnology.
Over the past 20 years, pathogenic fungi have developed growing resistance to anti-fungal drugs. This stimulated a strong demand for more effective drugs and led to the successful research at Syracuse. The researchers’ genomic study suggests that furanones have different genetic targets than current anti-fungal agents and thus may avoid drug resistance acquired in the past.
The research team has also shown previously that these furanones inhibit bacterial biofilm formation; thus they may help control chronic infections where biofilms often appear, on surgical, dental and other implants.
Ongoing furanones research at Syracuse University will investigate a broad spectrum of other potential capabilities, ranging from diverse medical uses, such as controlling bacterial and fungal biofilms, to anti-fungal wood preservatives for the building materials market.
Ray Wimer, professor of retail practice in the Whitman School, was interviewed for the International Business Times piece “Can JC Penny Perform a Magic Act As It Emerges From Bankruptcy?” Wimer, an expert on the retail industry, says that the…
Mark Pollitt, adjunct professor in the School of Information Studies, was interviewed for the TODAY story “How the FBI is following a digital trail of evidence to track down capitol rioters.” Pollitt spent a thirty year career working for the…
Shubha Ghosh, the Crandall Melvin Professor of Law in the College of Law, was quoted in the Katie Couric Media piece “Did President rump’s Ban from Twitter Violate Free Speech? The experts say not exactly.” Ghosh, an expert in antitrust…
Scott Landes, associate professor of sociology in the Maxwell School, was quoted in The Washington Post story “People with disabilities desperately need the vaccine. But states disagree on when they’ll get it.” Landes, an expert on the sociology of disability,…
Luvell Anderson, associate professor of philosophy in the College of Arts and Sciences, wrote commentary in the Boston Review titled “Whiteness Is the Greatest Racial Fraud.” Anderson, who studies the philosophy of race, uses the piece to discuss the concept…
If you need help with your subscription, contact sunews@syr.edu.
